AP214 ameliorates sepsis-induced acute kidney injury and mor(12)

NIH-PA Author Manuscript

NIH-PA Author Manuscript

NIH-PA Author ManuscriptFigure 2. Effect of AP214 on AKI induced by CLP

Mice were sacrificed 18 hr after lethal CLP surgery for measurement of serum creatinine byHPLC method. AP214 was injected at 0, 6 hr (A, B) or only at 6 hr (delayed-treatment) (C).Equimolar native α-MSH (6.8 μg) was injected at 0 and 6 hr (B). Values are mean ± SEM (n= 4～5 in sham-operated group, n = 10～14 in CLP group, n = 7～10 in each AP214 treatmentgroup). #, P < 0.05 vs. CLP.