AP214 ameliorates sepsis-induced acute kidney injury and mor(18)

Doi et al.

NIH-PA Author Manuscript

NIH-PA Author Manuscript

NIH-PA Author ManuscriptPage 19Figure 8. Immunohistochemical analysis of activated caspase-3 in spleen

Immunohistochemistry with anti-activated caspase-3 antibody in sham-operated group (A),CLP group (B), AP214-treated group (C); Original magnification: X400. Counts of positivestained cells were shown. AP214 was injected at 0 and 6 hr (D) or only at 6 hr (delayed-

treatment) (E). Values are mean ± SEM (n = 3 in sham-operated group, n = 5 in CLP group, n= 5 in AP214 group). #, P < 0.05 vs. CLP.