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YETIYeast Exploration Tool Integrator(2)

发布时间:2021-06-06   来源:未知    
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Summary: Yeast Exploration Tool Integrator (YETI) is a novel bioinformatics tool for the integrated visualization and analysis of functional genomic data sets from the budding yeast Saccharomyces cerevisiae. Availability: YETI is freely available for use o

YETI

Fig.1.YETIscreenshots:(A)genomeschematic;(B)chromosomescrolling;(C)proteininteractionmap;(D)interactivedatatable.

bioinformaticianstocarryoutcollectiveanalysesofthedatasets.Inaddition,twonewsectionsarecurrentlyunderdevel-opment.ATranscriptomeSectionwillprovideameansforeffectivelyvisualizingandanalysingdatafromgeneexpres-sionmicroarraysusingbothclusteringalgorithmsandprin-cipalcomponentanalysisandaCellSectionwillprovideaccesstometabolicpathways.AlthoughYETI’sdesignisspe-ci callyaimedatS.cerevisiae,theframeworkoftheprogramcouldbeappliedtootherorganismswithease.

ACKNOWLEDGEMENTS

WewouldliketothankProf.JeanBeggsandherlaboratoryattheUniversityofEdinburghfortheircontinuedsupportandadvice.R.J.O.issupportedbyaSpecialBioinformaticsStudentshipfromtheMedicalResearchCouncil.

REFERENCES

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Ito,T.,Chiba,T.,Ozawa,R.,Yoshida,M.,Hattori,M.andSakaki,Y.(2001)Acomprehensivetwo-hybridanalysistoexploretheyeastproteininteractome.Proc.NatlAcad.Sci.,98,4569–4574.

Mewes,H.W.,Albermann,K.,Heumann,K.,Liebl,S.andPfeiffer,F.(1997)MIPS:adatabaseforproteinsequences,homologydataandyeastgenomeinformation.NucleicAcidRes.,25,28–30.Mrowka,R.(2001)AJavaappletforvisualizingprotein–proteininteraction.Bioinformatics,17,669–670.

Uetz,P.,Giot,L.,Cagney,G.,Mans eld,T.A.,Judson,R.S.,Knight,J.R.,Lockshon,D.,Narayan,V.,Srinivasan,M.,Pochart,P.etal.(2000)Acomprehensiveanalysisofprotein–proteininter-actionsinSaccharomycescerevisiae.Nature,403,623–627.

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