(论文中英文摘要格式)(5)

(论文中英文摘要格式)

ABSTRACT

This dissertation consists of five chapters. Reported in chapter 1 were the studies of chemical constituents from Schisandra lancifolia and the evaluation of anti-HIV activities. In second chapter, we described the isolation and identification of chemical constituents from Schisandra rubriflora and the screening results of anti-HIV activities. The third and the fourth chapters introduced the chemical constituents from Angelica apaensis and Heracleum rapula respectively, and their inhibitory effects on rabbit platelet aggregation induced by PAF, AA and APD were also reported. The last chapter, we summarized new naturally occurring cycloartane-type triterpenoids (1999-2004).

As a result, 129 compounds were isolated from these plants, and their structures were established on the basis of spectral methods and X-ray crystallographic analysis, which concerned triterpenoids, flavanones, coumarins, iridoids, steroids, lignans and aromatic compounds. Among them, 32 compounds were proved to be news ones.

The bioactivities of compounds isolated from the above mentioned plants have been tested, including anti-HIV-1, cytotoxities against C8166 and MT-4 cells and anti-platelet aggregation activity. Five compounds showed obvious anti-HIV-1 activities with SI values more than 43. The obvious anti-HIV-1 activities make them as promising lead compounds or assistant drug for the preparation of anti-HIV drugs. Further anti-HIV evaluation is in progress to better define the anti-HIV potencies of them. Such a study would provide valuable information on the therapeutic development of new generation for anti-HIV drug.

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