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The transcriptional regulatory repertoire of Corynebacterium(4)

发布时间：2021-06-06 来源：未知

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176K.Brinkrolfetal./JournalofBiotechnology149 (2010) 173–182

Table1

FeaturesandphysiologicalrolesoftranscriptionregulatorsinCorynebacteriumglutamicumATCC13032.Codingregioncg0012cg0019cg0051cg0090cg0112cg0156cg0196cg0215cg0313cg0317cg0337cg0350cg0444cg0454cg0500cg0527cg0702cg0800cg0862

Alternativeidenti erNCgl0009NCgl0015NCgl0035NCgl0068NCgl0082NCgl0120NCgl0154NCgl0171NCgl0253NCgl0257NCgl0275NCgl0286NCgl0358NCgl0368NCgl0405NCgl0430NCgl0581NCgl0668NCgl0721

GenenamessuR––citBureRcysRiolRcspAlrparsR2whcAglxRramB–qsuRglyR–prpRmtrA

ProteinfamilyROKLysRAraC

ResponseregulatorMarRROKGntRColdAsnCArsRWhiBCrpHTHTetRLysRArsRLysRHTHResponseregulator

Numberoftargetgenesa

913471810132815055341134

EvidencebEPPEPEEEEEPEEPEEPEE

Regulatoryroleandphysiologicalfunctionoftranscriptionregulatorc

Activatorofsulfonateandsulfonateesterutilizationgenes

Activatorofmembraneproteingenecg0018ActivatorofABC-typetransportergenescg0052–cg0054

ActivatorofcitratetransportergenescitHandtctCBA

RepressorofureasegenesureABCEFGD

Dualregulatorofassimilatorysulfatereductiongenes

RepressorofinositolmetabolismgenesRepressorofmalatesynthasegeneaceB

ActivatorofaminoacidexportergenesbrnFERepressorofarsenitepermeasegenearsB2andarsenatereductasegenearsC2

RepressorofoxidativestressresponsegenesDualregulator(globalregulator)functioningasnetworkhub

Dualregulator(masterregulator)ofcarbonmetabolism

RepressorofMFS-typetransportergenescg0455andcg0456

ActivatorofquinateandshikimateutilizationgenesqsuABCD

ActivatorofserinehydroxymethyltransferasegeneglyA

Activatorofsecondarytransportergenecg0701ActivatorofpropionateutilizationgenesprpD2B2C2

Dualregulatorofgenesinvolvedincellmorphology,antibioticssusceptibilityandosmoprotection

ECFsigmafactor(masterregulator)involvedinglobalstressresponse

ActivatorofthioredoxingeneclustertrxBC-cwlM

ActivatorofpyridoxalphosphatesynthasegenespdxST

RepressorofABC-typetransportergenescg0977andcg0978

Repressor(masterregulator)ofnitrogenmetabolism

Repressorofsecondarytransportergenecg0992Repressorofsecondarytransportergenecg1033RepressorofMmpL-typetransportergenecg1054

Repressorofgenesforironprotein

RepressorofMFS-typetransportergenecg1212RepressorofNADbiosynthesisgenesnadAC-cg1214

ECFsigmafactorinvolvedinresponsestocellsurfacestresses

Repressorofhydroxyquinolpathwaygenescg1310andcg1311

Dualregulator(masterregulator)ofrespirationRepressorofriboseuptakeanduridineutilizationgenes

ActivatorofaminoacidexportergenelysERepressorofleucineandtryptophanbiosynthesisgenes

Repressorofuridineutilizationandriboseuptakegenes

Repressorofquinoneoxidoreductasegeneqor2RepressorofargininebiosynthesisgenesRepressorofABC-typetransportergenescg1652–cg1649andcg1653

RepressorofarsenitepermeasegenearsB1andarsenatereductasegenesarsC1andarsC1’Repressorofaconitasegeneacn

Repressorofiron–sulfurclusterbiogenesisgenes

RepressorofpyrimidinebiosynthesisgenesRepressorofABC-typetransportergenescg1832–cg1834

cg0876cg0878cg0897cg0979cg0986cg0993cg1032cg1053cg1120cg1211cg1218cg1271cg1308cg1340cg1410cg1425cg1486cg1547cg1552cg1585cg1648cg1704cg1738cg1765cg1817cg1831

NCgl0733NCgl0734NCgl0753NCgl0823NCgl0829NCgl0836NCgl0869NCgl0886NCgl0943NCgl1019NCgl1025NCgl1075NCgl1110NCgl1138NCgl1203NCgl1215NCgl1261NCgl1312NCgl1317NCgl1345NCgl1401–

NCgl1483NCgl1504NCg1551lNCgl1563

sigHwhcEpdxR–amtR–––ripA–nrtRsigE–arnRrbsRlysGltbRuriRqorRargRrpiRarsR1acnRsufRpyrR–

SigmafactorWhiBGntRPadRTetRArsRArsRTetRAraCArsRNrtRsigmafactorTetRCOG2345LacILysRIclRLacICOG1733ArgRRpiRArsRTetRArsRPyrRArsR

583233922218141379191029632743

EPEEEPEEEPPEEEEEEEEEPEEEEP

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