During the next decade a tremendous advance will take place in instrumentation for spectroscopy of the interstellar medium. Major new facilities (ALMA, SOFIA, APEX, LMT, Herschel and others) will be constructed and commissioned, so that the science opportu
10Phillips,Vastel:Futuremmandsubmminstrumentation
tionoftheinterstellarmediumwhichiscoldenoughforstrongfractionationandCOdepletion(fC)approaches10 3,thentherewillbeasigni cante ect:fD×fC≥10 3
(11)
WeknowthatfD~10 1,ormoreinsomecases,soiffC≥10 2,measuredvaluesofthedeuteriumabundancemaybesigni cantlya ected.
Acknowledgements
WeacknowledgesupportfromtheNSFundercontractAST-9980846.WethankEricHerbst,JohnPearson,TomMillarandDieterGerlichforhelpfulconversations.Wearealsograte-fultoPaulGoldsmithforprovidingusthe guresofSWASobservationstowardsSgrB2,W49NandW51.
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