201012-1335嗯嗯呃(7)

嗯嗯呃

- 7 - 中国科技论文在线expansion of islets and significantly reduced the injuries of pancreas. The damage of pancreas tissues was mended in the trans-tiliroside treated diabetic group and metformin-treated diabetic group at some degree (Fig. 3C –E).

Fig.3. Effect of the trans-tiliroside on the histological morphology of mice pancreas (H&E200). (A) Normal

control mice showed normal pancreas. (B) STZ treatment elicited severe injury of pancreas and the islets were shrunken severely. (C and D) The trans-tiliroside (1.2 and 0.3 mg/kg) significantly reduced the degree of the

injuries of pancreas. (E) Metformin (93.75 mg/kg)-treated mice pancreas.

3 Discussion

Plant-derived flavonoids have recently increased importance because they have been shown to have a wide range of biological activities, including antiallergic, antibacterial, antidiabetic, antiinflammatory, antiviral, antiproliferative, hepatoprotective, insecticidal, and antioxidant activities [12-15]. Interest in the therapeutic applications of flavonoids as potential anti-diabetic agents has increased in recent years. The beneficial effects of several flavonol glycosides have been demonstrated in relation to diabetes mellitus, through acting at multiple sites of glucose regulatory pathways, e.g. glucose tolerance, lipid profile, glycogen biosynthesis, glucose uptake and insulin release [16,17].

Although many bioactivities of the principal constituent, trans-tiliroside were reported, such