siRNA非病毒递送载体的研究现状(8)

siRNA 非病毒 递送载体 现状

杨飞飞等: siRNA非病毒递送载体的研究现状

· 1443 ·

[J]. Bioconjug Chem, 2011, 22: 1673 1681.

[52] Kim WJ, Christensen LV, Jo S, et al. Cholesteryl oligoarginine

delivering vascular endothelial growth factor siRNA effectively inhibits tumor growth in colon adenocarcinoma [J]. Mol Ther, 2006, 14: 343 350.

[53] Wang W, Tang N, Zhang CL, et al. Cell penetrating peptides

enhance intracelluar translocation and function of siRNA encapsulated in PEGylated liposomes [J]. Acta Pharm Sin (药学学报), 2006, 41: 142 148.

[54] Wang YH, Hou YW, Lee HJ. An intracellular delivery

method for siRNA by an arginine-rich peptide [J]. J Biochem Biophys Methods, 2007, 70: 579 586.

[55] Simeoni F, Morris MC, Heitz F, et al. Insight into the mechanism

of the peptide-based gene delivery system MPG: implications for delivery of siRNA into mammalian cells [J]. Nucleic Acids Res, 2003, 31: 2717 2724.

[56] Dassie JP, Liu XY, Thomaset GS, et al. Systemic administration

of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors [J]. Nat Biotechnol, 2009, 27: 839 849.

[57] Shu Y, Cinier M, Guo PX, et al. Assembly of multifunctional

phi29 pRNA nanoparticles for specific delivery of siRNA and other therapeutics to targeted cells [J]. Methods, 2011, 54: 204 214.

[58] Zheng XZ, Du LF, Chang J. Advance in administration

routes of siRNA [J]. Biomed Eng Clinic Med (生物医学工程与临床), 2009, 13: 461 464.

[59] Wang QX, Wang JJ, Xu GX. Progress of RNAi drugs in

clinical research [J]. Pharm Clin Res (药学与临床研究), 2010, 18: 127 130.

[60] Behlke MA. Progress towards in vivo use of siRNAs [J].

Mol Ther, 2006, 13: 644 670.

[61] DeVincenzo J, Cehelsky JE, Alvarez R, et al. Evaluation

of the safety, tolerability and pharmacokinetics of ALN- RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV) [J]. Antiviral Res, 2008, 77: 225 231.

[62] Oh YK, Park TG. siRNA delivery systems for cancer treatment

[J]. Adv Drug Deliv Rev, 2009, 61: 850 862.

[63] Castanotto D, Rossi JJ. The promise and pitfalls of RNA-

interference-based therapeutics [J]. Nature, 2009, 457: 426 433.

[64] Davis ME, Zuckerman JE, Choi CH, et al. Evidence of RNAi

in humans fromsystemically administered siRNA via targeted nanoparticles [J]. Nature, 2010, 464: 1067 1070.

[65] Guo JJ, Wang JJ, Xu GX, et al. Pharmacokinetic perspective

and the delivey of siRNA in vivo [J]. Pharm Clin Res (药学与临床研究), 2010, 18: 363 369.

[66] Walsh AS, Yin HF, Erben CM, et al. DNA cage delivery to

mammalian cells [J]. ACS Nano, 2011, 5: 5427 5432.