多肽合成中困难序列的缩合研究进展(9)

非常详细的综述性文章

17.Yan B The properties of resin supports and their effects on solid-phase organic synthesis 199818.Varanda LM;Miranda MTM Solid-phase peptide synthesis at elevated temperatures:a search for andoptimized synthesis condition of unsulfated cholecystokinin-12 1997

19.Pennington MW;Zaydenberg I;Byrnes ME Synthesis of the cardiac inotropic polypeptide anthopleurinA 1994

20.Clippingdale AB;Macris M;Wade JD Synthesis and secondary structural studies of penta (acetyl-Hmb)A beta(1 -40) 1999(6)

21.Chan WC;White PD Fmoc Solid Phase Peptide Synthesis--a Practical Approach 2000

22.Gatos D;Tzavara C Comparison of the solid-phase fragment condensation and phase-change approachesin the synthesis of salmon I calcitonin 2001

23.Ball HL;King DS;Cohen FE Engineering the prion protein using chemical synthesis 200124.DalPozzo A;Ni M;Muzi L Amino acid bromides:their N-protection and use in the synthesis ofpeptides with extremely difficult sequences 2002

25.Garcia-Martin F;Quintanar-Audelo M;Garcia-Ramos Y ChemMatrix,a poly (ethylene glycol)-basedsupport for the solid-phase synthesis of complex peptides 2006

26.Leena S;Kumar KS Syntheses,characterization and application of cross-linked polystyrene-ethyleneglycol acrylate resin (CLPSER) as a novel polymer support for polypeptide syntheses 200127.Tickler AK;Barrow CJ;Wade JD Improved preparation of amyloid-beta peptides using DBU as Nalpha-Fmoc deprotection reagent 2001

28.May PJ;Bradley M;Harrowven DC A new method of forming resin bound thioesters and their useas'traceless' linkers in solid phase synthesis 2000(10)

29.Meutermans WD;Bourne GT;Golding SW Difficult macrocyclizations:new strategies for synthesizinghighly strained cyclic tetrapeptides 2003(15)

30.Miranda LP;Meutermans WD;Smythe ML An activated O→ N acyl transfer auxiliary:efficientamidebackbone substitution of hindered "difficult" peptides 2000

31.Sohma Y;Sasaki M;Hayashi Y Design and synthesis of a novel water-soluble Aβ1-42 isopeptide:anefficient strategy for the preparation of Alzheimer's disease-related peptide,Aβ1 -42,via O-Nintramolecular acyl migration reaction 2004(31)

32.Sampson WR;Patsiouris H;Ede NJ The synthesis of "difficult" peptides using 2-hydroxy-4-methoxybenzyl or pseudoproline amino acid building blocks:a comparative study 1999

33.Mutter M;Nefzi A;Sato T Pseudo-prolines (psi Pro) for accessing "inaccessible" peptides 199534.Bellanda M;Peggion E;Burgi R Conformational study of an Aib-rich peptide in DMSO by NMR 2001

相似文献(1条)

1.期刊论文 郑彦慧.张艳平.张浩.马玉新.路延龄.史作清.ZHENG Yan-Hui.ZHANG Yan-Ping.ZHANG Hao.MA Yu-Xin.LU Yan-Ling.SHI Zuo-Qing Fmoc保护氨基酸与Wang树脂的缩合反应 -高等学校化学学报2008,29(9)

研究了保护氨基酸、 Wang 树脂取代度、树脂粒度、搅拌方式对Fmoc-氨基酸-Wang树脂连接效率的影响. 结果表明, 保护氨基酸分子量的大小会因产生不同的位阻而影响缩合反应的效率, 分子量越小缩合效率越高;Wang树脂的取代度较高时, 已缩合的氨基酸给后续保护氨基酸的缩合形成阻碍, 使缩合效率降低;粒径较小和搅拌较好时, 对保护氨基酸的粒内外扩散有利, 可提高反应速度和缩合效率.